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Search Results for " estrogen receptor "

20

Compounds

Cat No. Product Name Synonyms Targets
T15249 Estrogen receptor modulator 1 Estrogen Receptor/ERR
Estrogen receptor modulator 1 causes regression of Tamoxifen-resistant, hormone-independent xenograft tumors. Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM) (pIC50: 0.4...
T78646 Estrogen receptor antagonist 8 Estrogen Receptor/ERR
Estrogen Receptor Antagonist 8 exhibits potent antagonistic activity against the estrogen receptor (ER), demonstrating effective anti-uterotrophic potential in vivo, with an EC50 value of 4.160 μM.
T40893 Estrogen receptor modulator 6
Estrogen receptor modulator 6 (compound 3a) is a highly specific and potent agonist of the estrogen receptor (ER) β with a remarkable affinity (K i = 0.44 nM). This compound exhibits an impressive 19-fold selectivity for...
T11236 Giredestrant tartrate Estrogen receptor antagonist 1 Estrogen Receptor/ERR , Others
Giredestrant tartrate (Estrogen receptor antagonist 1) is a novel, orally active, selective and effective non-steroidal estrogen receptor antagonist. Giredestrant tartrate strongly binds to ER, resulting in the failure o...
T11237 Camizestrant Estrogen receptor antagonist 2 Estrogen Receptor/ERR
Camizestrant (Estrogen receptor antagonist 2) is an antagonist of the estrogen receptor and can be used in studies about ER+ HER2-advanced breast cancer[1].
T4388 PHTPP Estrogen Receptor/ERR , Estrogen/progestogen Receptor
PHTPP is a selective ERβ antagonist.
TN1052 Lindleyin Estrogen Receptor/ERR , Estrogen/progestogen Receptor
Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.
T13768 (+)-Medicarpin Estrogen/progestogen Receptor
(+)-Medicarpin, a pterocarpan, is an isoflavonoid compound derived from multiple medicinal plant species such as Sophora japonica, Zollernia paraensis, Platymiscium yucatamun, Machaerium aristulatum, and Platymiscium flo...
T5S0543 Isocurcumenol Apoptosis , Estrogen Receptor/ERR , Reductase
1. Isocurcumenol inhibits 5α-reductase which converts testosterone to dihydrotestosterone (DHT).
T7904 SR 19881 Estrogen/progestogen Receptor
SR 19881 is a full agonist of ERRγ(EC50 value of 0.39 μM in a binding assay and an EC50 value of 4.7 μM in a cell-based assay).
T8984 FLTX1 Estrogen Receptor/ERR , Estrogen/progestogen Receptor
FLTX1 is a fluorescent derivative of Tamoxifen, designed to efficiently target and label intracellular Tamoxifen-binding sites (estrogen receptors) both under permeabilized and non-permeabilized conditions. Additionally,...
T62952 Estrogen receptor antagonist 5
Estrogen receptor antagonist 5 is a potent antagonist of the Estrogen receptor. Estrogen receptor (Estrogen receptor) is a ligand-activated transcriptional regulatory protein that interacts with endogenous estrogens and ...
T63582 Estrogen receptor antagonist 1
Estrogen receptor antagonist 1 is a potent antagonist of the estrogen receptor. Estrogen receptor antagonist 1 has shown research potential in breast cancer disease.
T79064 Estrogen receptor modulator 7 Estrogen Receptor/ERR
Estrogen Receptor Modulator 7 is a potent modulator of estrogen receptors, utilized in cancer research [1].
T60293 Estrogen receptor-IN-1
Estrogen receptor-IN-1 (compound 16) is an effective estrogen receptor (ER) inhibitor with IC 50 s of 13, 5μM for ERα and Erβ, respectively [1].
T63277 Estrogen receptor antagonist 2
Estrogen receptor antagonist 2 is a selective down-regulator of estrogen receptor. Estrogen (E2) and estrogen alpha receptor (ERα) are important drivers of breast cancer development. estrogen receptor antagonist 2 has re...
T63914 Estrogen receptor antagonist 3
Estrogen receptor antagonist 3 is a potent degradation agent of the estrogen receptor (ER). Estrogen signalling systems play an important role in the regulation of cell growth, differentiation and apoptosis, and Estrogen...
T63106 Estrogen receptor antagonist 4
Estrogen Receptor Antagonist 4 is a potent inhibitor of the estrogen receptor (ER), crucial for regulating cell growth, differentiation, and apoptosis. This compound holds promise for cancer research[1].
T79109 Estrogen receptor modulator 8 Estrogen Receptor/ERR
Estrogen Receptor Modulator 8 (compound 4) is an orally active inhibitor targeting Estrogen Receptor/ERR α with potent efficacy (IC50 = 0.437 nM in MCF-7 cells) and effectively hampers MCF-7 cell proliferation (IC50 = 0....
T39710 ARV-471 Vepdegestrant Estrogen Receptor/ERR
ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.
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